Where to Stay: Adam's Mark Hotel
A great downtown option, Adam's Mark Hotel sits just across from the Gateway Arch. Rates from $119.
4th Chestnut; (314) 241-7400 or www.adamsmark.com
Where to Eat: Imo's
St. Louisians prefer their pizzas topped with Provel cheese, a blend of provolone, Cheddar, and Swiss. The consistency is more like Alfredo sauce than stringy mozzarella, but the rich flavor puts a tasty new spin on pizza. Try it at Imo's, a chain famous for slicing its pies into squares.
4479 Forest Park; (314) 535-4667 or www.imospizza.com