We adore Hotel Monaco. It's a modern boutique hotel with bright colors, distinctive furnishings, and sumptuous linens. Nearby chain hotels include Courtyard Washington Convention Center, Grand Hyatt, and Renaissance Washington DC Hotel.
Penn Quarter is super-easy to navigate. You can get to any attraction quickly and cheaply. Two Metro stations service the area: Archives-Navy Memorial-Penn Quarter and Gallery Place-Chinatown. The D.C. Circulator bus connects Penn Quarter to Georgetown, Union Station, and the National Mall.